Synthesis of Chitosan –g-Acrylamide-Co-Acrylic Acid /Ag Nanocomposite For Extended Wound Healing Application

Abstract

New nanocomposite based on chitosan and acrylamide and silver nanoparticles has been prepared to produce wound dressing has superior properties as Hemostatic and antibacterial activity. Chitosan successfully grafted with acrylamide via free radical copolymerization using potassium persulphate. Four different chitosan grafted acrylamide prepared and fully characterized through nitrogen content and ATR/IR. Cs-g- PAAM partially hydrolyzed at basic condition in presence of silver nitrate in order to prepare Cs-g-PAAm-co-PAAc/Ag nanococomposite. The optimum condition for preparing homogenous and well distributed was examined using grafted polymers were characterized using TEM and UV-vis absorption. Cs:PAAm (1:1) pH 11 and 120 min showed homogenous spherical silver nanoparticles and distributed particles lying at nanosize range between 10-30 nm. SEM-EDX and XRD used to confirm binding silver to chitosan hybrid chains forming newly nanocomposite. Produced composite showed complete solubility at neutral medium condition that qualifies produced composite to be used at different medical and industrial applications.