ACUTE TOXICITY OF HYDROXYUREA IN MALE ALBINO MICE

Abstract

This study was carried out to investigate the acute oral toxicity LD50 of an anti-neoplastic and a chemotherapeutic agent hydroxyurea in male albino mice by using up α Down method. The result revealed that LD50 of hydroxyurea was (7868.5 mg/kg. b.w). Orally after 24 h of exposure. That’s mean it is slightly toxic agent. To study the effect of lethal doses of hydroxyurea on the some of blood parameters, two survival animals were taken from this study which was received (7000 mg/kg. b.w and 7500 mg/kg. b.w ) orally and compared with normal values of blood parameters in male albino mice. The results revealed there is an increase in Hb comparing with the normal values and the increase was dose dependent manner, while the results showed decrease of RBCs, WBCs, PCV and lymphocytes in animals received hydroxyurea comparing with the normal values and the decrease was dose dependent manner