Biofilm. IMDs. Quorum Sensing: A Review

Abstract

Abstract: Biofilm is a castle or shield of microbes in nature, human and animals. Contamination of our ground water sources pose concerns for the future of our potable water supplies; this threat is accentuated by the stability that biofilms of these contaminants bring into equation. Biofilms are believed to be associated with human infections including chronic, recurrent and device‐related infections such as Urinary catheters, endotracheal tube, artificial joint prostheses, Intrauterine (IUDs), artificial heart values and contact lenses, therefore, treatment of biofilm infections has become an important focus in modern medicine. As planktonic susceptibility testing, via. the Minimal Inhibitory Concentration (MIC) test, provides little guidance in the selection of antimicrobials to treat biofilms, a change in paradigm is required to determine appropriate treatment of biofilms and for the discovery of next‐generation antimicrobials. Finally, we now recognize that MIC values provide us with little relevant information on how to treat biofilm infections. Clearly, a new paradigm for treatment biofilm is needed and the microbial biofilms as Enemies for human and animals but in other hand some of advantage biofilms conceder as friends with us.