Effects of the Extracts of Olive and Morus Alba Leaves on Experimentally STZ Induced Diabetes in Male Rats

Abstract

Fifty adult male albino rats (weighting 150 -200 g) were used and divided into 5 groups (10 rats of each). The first group was served as control group. The remaining groups were injected (i.p) by streptozotocin (STZ) at 45 mg/kg b.wt to induce diabetes. The 2nd diabetic group was used as control diabetic group. The third diabetic group was treated with Cidophage (500 mg/kg, orally).While, the fourth and fifth diabetic groups were treated with alcoholic Olive leave and Morus alba leave extracts (500 mg/kg b.wt, 600 mg/kg b.w orally, respectively). Treatment was performed daily for successive 30 days. The levels of blood glucose, albumin, total protein and creatinine were measured at 1 day, 1 and 2 weeks after the end of treatments of diabetic groups. The rats were sacrificed at the end of 30days post treatment. The obtained results showed that the use of Olive leave and morus alba leave extracts improved the levels of blood glucose, albumin, total protein and creatinine of diabetic rats. Moreover, Olive leave extract and morus alba leave extractsare capable of improving the impaired above parameters of STZ diabetic animals.