Synthesis and Characterization of Acetaminophen (paracetamol)® from Acetanilide by Diazotization Reaction and Comparing with Crude

Abstract

This study describes the synthesis of acetaminophen is quite easy by new method via diazotization reaction. The prepared compound that is initiated from acetanilide as the first step of the reaction followed by nitration reaction of acetanilide to form p-nitroacetanilide , reduction of the final product to form p-aminoacetanilide, and creating a diazonium salt that is then reacted with solution of (10%,2.5M) sodium hydroxide . The prepared product was matched with the crude of paracetamol and the bands of FT.IR spectra of the product also was matched with FT.IR characterization of paracetamol tablets and the melting point too. The product which was carried out successfully by new path was very largely familiar in the chemical processes .The final produced yield 70 % as possible