Salivary Sialic Acid Level and Oral Health Statues in Sample of Iraqi Children

Abstract

Background: Saliva is the 1st defense fluid with sialic acid is a significant salivary biomarker. It is an acidic sugar with a nine-carbon backbone, able to mediate a wide variety of patho- physiological processes. the study aims at estimate salivary sialic acid in Iraqi children sample and also find out their association with oral health status. Method: Unstimulated salivary samples were collected from 100 healthy child, aged 6-13 years for 5-minutes, between 9:00 - 11:00 A.M. gingival index(GI) and Plaque index were measured . According to WHO criteria,the dentition status was examined by dmfs, dmft,DMFS and DMFT. Also, flow rate and the level of salivary sialic acid were estimated. Results: In the present study,a positive correlation coefficient is recorded between the salivary flow rate and age and statistically reach the level of significance. Sialic acid concentration increased with age, but did not reach the level of significant. A male gender showed increase salivary sialic acid level by 0.2 U/L compared to female, but fail to reach the significance GI and DMFs showed a positive association with sialic acid level (R=0.036,R= 0.0053),but it’s not reach the significant. While sialic acid level observed that a significant weak inverse liner correlation with other variables like DMFS and PI,(R=- 0.082,R=-0.066) The outcomes were exposed to t-test and Pearson’s correlation coefficient, Plaque index, GI, flow rate and the dental caries status were significantly positive correlated with the sialic acid levels in saliva. Conclusion: The salivary factors evaluated in this study may prove to be useful measures for gingival inflammation in children and allow pediatric dentists to target preventive measures appropriately