Green synthesis of ZnO nanoparticles in grape extract: Their application as anti-cancer and anti-bacterial

Abstract

Zinc oxide nanoparticles (ZnO NPs) have been synthesized using a reduction agent from aqueous grape extract (Vitis vinifera). ZnO NPs were investigated by utilizing the UV–Visible spectrum of the biosynthe sized optical properties at 373 nm. ZnO NPs were characterized by transmission electron microscopy, atomic force microscopy, and scanning electron microscopy. The X-ray diffraction pattern of ZnO NPS exhibited a wurtzite (hexagonal) crystalline structure. Fourier transform infrared spectroscopy exhibited a stretching vibration of Zn-O at 408.91 cm 1 . The bactericidal activity of ZnO NPs showed a significant inhibitory activity against pathogenic bacterial strains, which was investigated against Gram-negative bacterial strain Klebsiella pneumoniae and Gram-positive bacterial strain Staphylococcus aureus. Furthermore, ZnO NPs showed significant cytotoxicity against human breast cancer (MCF-7) and brain cancer (AMGM5) cell lines. Therefore, the study reveals that grape extract is an effective reducing agent for the formation of ZnO NPs, which exhibits biological properties. 2021 Elsevier Ltd. All rights reserved.Selection and Peer-review under responsibility of the scientific committee of the EurasiaNanotechnology Conference.