The protective effect of hydroalcoholic extracts of olive and morus alba leaves on liver enzymes of male rats treated with streptozotosin

Abstract

The objective of this study is to investigate the effects of Olive and Morus alba leaves extracts (ethanol hydro-alcohol 60%) on some liver enzyme {Serum aspartate aminotransferase (AST), Serum alanine aminotransferase (ALT)} in experimentally STZ induced diabetes in male rats. Fifty adult male albino rats weighting (150 -200 g) were used and divided equally into 5 experimental groups; the first group was served as a control group. The remaining groups were injected (i.p) by streptozotocin (STZ) at 45 mg/kg B.W to induce diabetes. The 2nd diabetic group was received as control diabetic group. The third diabetic group was treated with Cidophage (500 mg/kg, orally). While, the fourth and fifth diabetic groups were treated with Olive and Morus alba leaves extracts (500 mg/kg B.W, 600 mg/kg B.W orally) respectively. All treatment groups were given daily for successive 30 days. The levels of (AST and ALT) were measured at 1st day after end treatments. The rats were sacrificed at the end of 30 days of treatment. The obtained results demonstrated the use of Olive and Morus alba leaves extracts improve of (AST and ALT) levels of diabetic rats. Hydro-alcoholic extract of Olive and Morus alba leaves could improve the liver enzymes of male rats, an induced diabetes in male rats.