The clinical effectiveness and safety of PRP injections : single-spin versus two-spin centrifugation in facial rejuvenation

Abstract

The purpose of this study was to compare the clinical effectiveness and safety of PRP injections using either single-spin or two-spin preparation method. Fourty patients (all are females with ages between 21-56 years old) were included in this study. The patients are divided into two groups, the first group 20 patient were injected by PRP which was prepared by single centrifuge at 3000 rpm for 10 minute. The second group: 20 patientswere injected by PRP which was prepared by two centrifuge method where the first centrifuge was done at 3000 rpm for 10 minute for isolation of plasma then the plasma was condensed by second centrifuge at 3000 rpm for 10 minute then the PRP injected alone without platelet poor plasma (PPP). By using objective clinical assessment and subjective satisfaction scale revealed : In first group, 4 patient showed improvement with the score of 4.1-5 (80-100%), 6 patients with the score of 3.1-4 (60-80%), 6 patients with the score of 2.1-3 (40-60%) and 4patients with the score of 1.1-2 (20-40%) at the end of study.In second group, 3 patient showed improvement with the score of 4.1-5 (80-100%), 8 patients with the score of 3.1-4 (60-80%), 7 patients with the score of 2.1-3 (40-60%) and 2 patients with the score of 1.1-2 (20-40%). There are controversies regarding the optimal method of PRP preparation that produce the best clinical effectiveness. Within the limit of this study, the one-spin procedures produce comparable results with two-spin procedure for safe therapeutic application