FORMULA OF TYLOSIN20% INJECTION AQUEOUS SOLUTION ANTIBIOTIC FOR VETERINARY USE

Abstract

Tylosin belongs to macrolides, which have been classified as critically important antimicrobials in veterinary. The antibiotic of Tylosin is a preparation of a new formulation of veterinary injectable aqueous solution at a concentration of 20%. It was prepared under sterile conditions. The collected data are concerning the information of the materials used in the preparation of the formula from the “British pharmacopoeia; this information includes the physical and chemical properties of the active ingredient and additives used in the formulation. The physical properties are clear yellow viscous aqueous solutions free from undesired particles. The formula was tested by biological method at room temperature and activity was observed at 104%. On the other hand, the formula’s stability was stored at an incubator at temperatures (40, 50, 60ºC) with a humidity of 65% for seven months. In the first month, the activity result was observed to be 100%. While the continuous storage of the formula in seven months shows a ratio between 95% to 105%activity, which is within the allowed limits. At the same time, the acidic condition (pH) is varied between 5 and 7.5. The injection solution is used for the treatment of respiratory bacterial infection in large animals and also in the treatment of mastitis refractory. Finally, clinical evaluation and therapeutic effect examination were carried out in the veterinary hospital/Baghdad. The formula was used to treat respiratory inflammation in small and large animals. It was found that formula curing is efficient in most cases; this is another proof of the therapeutic leverage of the product in practice