PREPARATION AND CHARACTERIZATION OF MIXED COMPLEXES FOR SOME TRANSITIONAL ELEMENTS OF THE FLAVONOID LIGAND

Abstract

A group of mixed complexes formed by the reaction of simcarbazone and quercetin with chlorides of transition elements was prepared with a ratio of (1:1:1) ligand: metal and the study of some of their physical properties, where the complexes were diagnosed by ultraviolet spectroscopy techniques (Uv. – Vis) and Quantitative Analysis of Elemental Metals (C.H.N.M) These complexes were also identified by infrared radiation Spectra ( FTIR) In addition to the magnetic and molar electrical conductivity measurements, as well as the other mixed complexes were prohibited from the interaction of thiosemicarbazone and quercetin by (1:1:1) ligand: metal. With transitional elements diagnosed in the same ways above. The biological effect of the prepared ligands and their complexes on four genes of pathogenic bacteria was studied S. aureus, Ps. aeruginosa, E. coli, P. mirabilis. Measurements were made on the effectiveness of ALP, GPT, GOT and TSB for samples of blood serum of normal people and compared with the inhibition values of the blocked complexes. Most of the complexes showed an inhibitory effect, while the following complexes showed, [Ni(L1 )(L3 )Cl2 .H2O], [Co(L1)(L3 )Cl3 ] [Fe(L1 )(L2 )Cl] tonic effect.