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dc.contributor.authorAli, Hameed Hussein-
dc.contributor.authorAL-Rawi, Khalid-
dc.contributor.authorKhalaf, Yousif-
dc.contributor.authorAlaaraji, Shakir-
dc.contributor.authorAldahham, Bilal-
dc.contributor.authorAwad, Muthanna-
dc.contributor.authorAl-ani, Faisal-
dc.contributor.authorAli, Aus Tariq-
dc.date.accessioned2022-10-17T14:09:02Z-
dc.date.available2022-10-17T14:09:02Z-
dc.date.issued2022-07-
dc.identifier.issn2322-3480-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/2378-
dc.description.abstractBackground: The fluctuation in serum caveolin-1 (Cav-1) concentrations is an important indicator of many diseases. Irrespective of the actual cause, a significant reduction of serum Cav-1 is associated with a significant increase in insulin secretion and hyperinsulinemia. The aim of the current study was to evaluate the relationship between serum Cav-1, serum vaspin and visfatin in newly diagnosed men with T2DM. Methods: Eighty-two newly diagnosed men with T2DM were matched for age and body mass indexes (BMIs) with a similar number of non-diabetic men. Serum Cav-1, vaspin and visfatin were assessed through enzyme-linked immunosorbent assay. Fasting serum glucose (FSG), glycohaemoglobin A1C (HbA1c) were both measured using automated method. In addition, waist-circumferences, waist-hip ratio, systolic (SBP), and diastolic blood pressure (DBP) were also obtained. Results: Serum concentration of Cav-1(ng/mL) was significantly low in men newly diagnosed with T2DM, (2.334±0.7627) compared with non-diabetic controls (4.321±1.143), p< 0.0001. In contrast, patients with T2DM exhibited significantly higher serum concentrations of vaspin and visfatin (ng/mL), 142.4±60.53) and 2.99±1.091), than controls, 81.53±39.32) and 1.456±0.654), respectively, p< 0.0001. Expectedly, patients with T2DM have significantly higher FSG, HbA1c, systolic blood pressure (SBP), and diastolic blood pressure (DBP). Conclusions: There was an inverse significant relationship between Cav-1 and vaspin, visfatin, HbA1c, FSG, and hypertension. This study suggests that serum Cav-1 can be used as a diagnostic marker to predict T2DM in individuals and families under high risk.en_US
dc.language.isoenen_US
dc.publisherReports of Biochemistry & Molecular Biologyen_US
dc.subjectCaveolin-1, HbA1c, Insulin resistance, T2DM, Vaspin, Visfatin.en_US
dc.titleSerum Caveolin-1 Level is Inversely Associated with Serum Vaspin, Visfatin, and HbA1c in Newly Diagnosed Men with Type-2 Diabetesen_US
dc.typeArticleen_US
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