Effect of Local Implantation of Composite Biomaterial Loaded with Vascular Endothelial Growth Factor in Healing of Critical-Sized Mandibular Defect - A Pilot Study

Abstract

This study was aimed to establish the optimal effective concentration of VEGF in bone regeneration in vivo. Four male adult white New Zealand rabbits were equally divided into two experimental groups, A and B, which were also used as control. One circular critical size defect 8-mm Ø was created bilaterally in the mandibular body area of each rabbit. Group A received composite BCP/FS (Biphasic Calcium Phosphate/Fibrinogen Solution) with 250 ng/ml VEGF (Vascular Endothelial Growth Factor) on one side, and the control side received BCP/FS only. Group B received composite BCP/FS with 500 ng/ml VEGF on one side, and the control side received only BCP/FS. 4 weeks later, group B showed significant increase in bone formation compared to that of group A, and least bone formation in the control