HEPATITIS B AND RENAL FUNCTION OF PATIENTS WITH CHRONIC HEPATITIS B IN FALLUJAH DISTRICT, IRAQ

Abstract

Chronic Hepatitis B (HBV) is the leading cause of morbidity and mortality worldwide with about 248 million people having HBV infection. Presentstudy focused on the kidney function in patients with chronic hepatitis B. The aims of this study are: to estimate of the electrolytes in patients with chronic hepatitis B individuals. One hundred sixty patients’ samples and thirty healthy individuals were investigated in this study. The concentrations of Sodium, Potassium and Magnesium were determined using inductively Coupled plasma- Mass spectrometry (ICP-MS). Alanine amino transferase (ATL) and Aspartate amino transferase (AST) activities, total serum bilirubin (T.S.B), urea, Creatinine and amount of albumin were measured using standard laboratory methods. Viral load (HBV PCR) was also determined in all the examined patients. Results from this study showed that low serum albumin and higher serum T.S. B, S.ALT, S.AST urea and S. Creatinine with chronic hepatitis B compared to those of healthy individuals. The findings of this study show that the concentration range of Sodium element between (136.54±3.107mmol\l) to (140.51±3.598 mmol\l) was significantly lower in HBV infected patients as compared to those in healthy controls (142.82±3.37 mmol\l). Magnesium concentration range between (1.592989±.31mg/l) to (1.7319±.32468 mg/l) was significantly lower in HBV infected patients as compared to those in healthy controls(1.7477±0.17 mg\l). While, potassium concentration range between (4.61877±0.73 mmol\l) to (5.51846±0.736 mmol\l) was significantly higher in HBV infected patients as compared to those in healthy controls (4.4552±0.38 mmol\l). Positive and negative significant correlation relationships between the renal functions were reported between some groups. There are significant differences between some the renal functions in some groups and insignificant in other groups