Preparation, characterization and antibacterial activity of the 5- membered ring via Schiff's bases

Abstract

In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J1-J5 derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. Schiff's bases were synthesis by condensation of primary aromatic amine and aromatic carbonyl compounds. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J1-J5 derivatives. The compounds J1-J5 were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 μg.well-1 for J4 against the two pathogenic bacteria, while J1, J4, and J1 did not show any inhibitory effect against all bacteria. Finally, the 3'-(pyrimidin-2-yl) spiro[indoline-3,2'-oxazolidine]-2,5'-dione (J4) is the best compound synthesized inhibited the growth of gram-negative and positive bacteria