HEAVY METALS IN SERA OF PATIENTS WITH HEPATITIS B DETERMINATION AND ANALYSIS

Abstract

Chronic Hepatitis B is a major global health problem worldwide, However, two Billion People could be infected with this disease Worldwide. Living organisms require varying amounts of heavy metals. Such as manganese(Mn), cobalt(Co) and zinc(Zn). Some heavy metals have bio-importance, but the bio toxic effects of many of them in human biochemistry are of great concern. Heavy metals are essential micronutrients involved in many metabolic processes. One hundred sixty patient samples and thirty healthy individuals were investigated in this study. All patients included in this research are tested positive for the HBSAg test and their specimens were examined by profile test which includes (HBS Ab, HBe Ag, HBe Ab, HBc Ab ,(IgM-IgG), HCV and HIV) and also viral load (HBV PCR) with unit (copies/ml) were carried to test the patients sera. Manganese, chromium, cobalt, and nickel have levels were determined by using inductively Coupled plasma- Mass spectrometry (ICP-MS). Results show a significant increase in the concentration of manganese, chromium, cobalt, and nickel in serum of patients with chronic hepatitis B compared to healthy individuals. We conclude that hepatitis B may affect the level of studied elements in patients infected with HBV.