Evaluation study of the anti-ulcer activities of Cuminum cyminum Seed extract against ethanol induced gastric ulcer in rats

Abstract

A herbaceous and pharmaceutical plant Cuminum cyminum L is one of crop and famous international spice seed after black pepper. This work was conducted to evaluate the effect the plant seeds extract against ulcer in the stomach. To achieve this goal, fifty-five rats were isolated into five gatherings. Individually, every one of the studied rats was pre-treated by oral administration with water and omeprazole and 20 mg, 250, 500 and 800 mg per kilogram of plant extracts to rat for 60 min. After that the rats were treated with ethanol to induce gastric mucosal damage. After a period for another 60 min, the rats were anesthetized and sacrificed. The results obtained showed that the control group had severe mucus damage, whereas the rats treated with the seed extract showed a broad tolerance in a dosedependent manner. Further, Cuminum cyminum seeds extract (CCSE) brought about the high level of pH of the gastric environment and mucus production. In this way, it tends to be inferred that hydrous concentrate on Cuminum cyminum uncovers an enemy of ulcer undertaking in protection from ethanol by means of keeping up via maintaining the acid-base balance of gastric content