Association of cord blood asprosin concentration with atherogenic lipid profle and anthropometric indices

Abstract

Background: Elevated lipids in umbilical cord blood afect fetal programming, leading to a higher risk of developing cardiovascular disease in later life. However, the causes of changes in the lipid profle of umbilical cord blood are not clear yet. This study aimed for the frst time to determine the association of asprosin concentration with TAG, TC, HDL C, LDL-C concentrations and TAG/HDL-C, TC/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C ratio in umbilical cord blood as well as newborn anthropometric indices. This cross-sectional study was based on 450 mother- newborn pairs of a birth cohort study in Sabzevar, Iran. Multiple linear regression was used to estimate the association of lipid concentra‑ tion and lipid ratios as well as birth weight (BW), birth length (BL), head circumference (HC) and chest circumference (CC) with asprosin in cord blood samples controlled for the relevant covariates. Result: In fully adjusted models, each 1 ng/mL increase in asprosin was associated with 0.19 (95% CI 0.06, 0.31, P<0.01), 0.19 (95% CI 0.10, 0.29, P<0.01), 0.17 (95% CI 0.09, 0.25, P<0.01), 0.17 (95% CI 0.09, 0.25, P<0.01), 0.01 (95% CI 0.00, 0.013, P<0.01), 0.01 (95% CI 0.01, 0.01, P<0.01), 0.01 (95% CI 0.01, 0.01, P<0.01) and 0.01 (95% CI 0.01, 0.01, P<0.01) increase in TAG, TC, LDL-C, TAG/HDL-C, TC/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C ratio respectively. Moreover, higher asprosin levels was positively associated with newborn BW, BL, HC and CC; however, these associa‑ tions were not statistically signifcant. Conclusion: Overall, our fndings support the positive association between cord asprosin concentration and the development of atherogenic lipid profle in newborns. Further studies are needed to confrm the fndings of this study in other populations