Serum level estimation of some biomarkers in diabetic and non‑diabetic COVID‑19 infected patients

Abstract

Diabetes, hypertension, and cardiovascular disease all raise the risk of hospitalization and mortality in individuals infected with coronavirus disease 2019 (COVID-19). Higher levels of fogosis mediators such as TNF, C-reactive protein (CRP), IL-1, IL-6, leptin, and resistin, as well as increased levels of TNF, C-reactive protein (CRP), IL-1, IL-6, leptin, and resistin, defne diabetes. The goal of this study is to evaluate the levels of D-dimer, total serum bilirubin (TSB), glutamic-oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and CRP in diabetic patients with COVID-19 infection to COVID-19 patients without diabetes. Blood samples were collected from individuals with diabetes who had COVID-19 and non-diabetic COVID patients as control. Moreover, D-dimer and CRP were evaluated by using Min Vidus and Latx, respectively, whereas AccEnT 200 system was used to measure the serum level of TSB, GPT, and GOT in the hematology lab. Also demonstrated that the average serum concentration of D-dimer, GOT and CRP was high in diabetic COVID-19-infected patients (980.66 ng/mL, 67.71 U/L, and 27.06 mg/L, respectively) compared with non-diabetic COVID-19-infected patients (791.17 ng/mL, 54.023 U/L and 20.11 mg/L, respectively) (p<0.05), while the situation was inverse for the average concen tration of TSB and GTP when their average concentrations were low in diabetic COVID-19-infected patients (12.89 Mmol/L and 59.79 U/L, respectively) (p>0.05). Moreover, the cut-of values for serum D-dimer, TSB, GPT, GOT, and CRP of COVID-19-infected diabetic patients were≥6500 ng/mL,≥350 Mmol/L,≥133 U/L mg/L,≥150 U/L, and≥15.22 mg/L, respectively, represented a perfect test for predicting COVID-19-infected diabetic patients with 100% sensitivity and specifc ity. In conclusion, serum D-dimer, TSB, GPT, GOT and CRP increased in diabetic COVID-19-infected patients compared to non-diabetic COVID-19 patients and the D-dimer concentration also increases. TSB and CRP were more pronounced among diabetic patients with corona, while liver enzyme concentrations were decreased.