Study of the Cytotoxicity Effect of New Cr(III), Mn(II), Fe(III) and Cu(II) Complexes of Chalcone on Cancer (Cell Line RD) and Antimicribial Activity

Abstract

The new complexes of Cr(III), Mn (II), Fe(III) and Cu(II) complexes with the chalcone ligand were studied on the growth of Rhabdomyo sarcomas (RD) cell Line in human by using in vitro system and compared with anticancer drug cis platin (cis-pt) as appositive control. The cancer cells were treated with different concentration and cis-pt after 72 hr. exposure time. The cytotoxic activity was tested by inhibition rate as parameter. The results showed significant differences (p<0.05) for each three treatments when the inhibition rates were increased. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands. The synthesized complexes have been screened for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus, and new prepared complexes were compared with anticancer drug cis-platin.