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Title: | Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents |
Authors: | Al-Naseeri, Ali K. Alywee |
Keywords: | Chalcones, Pyrazolines, Isoxazolines, Antibacterial. |
Issue Date: | 2016 |
Publisher: | Baghdad Science Journal |
Abstract: | In this paper some chalcones (C1-C8) are prepared based on the reaction of one mole of substituted acetophenone with one mole of substituted benzaldehydes in the presence of (40%) sodium hydroxide as a base. Pyrazolines (P1–P8) are prepared from the reaction of chalcones (C1-C8) with hydrazine hydrate. Isoxazoline (I1-I8) is prepared from the reaction of chalcones (C1-C8) with hydroxyl amine hydrochloride in the presence of (10%) sodium hydroxide as a base. These compounds are characterized by using various physical and spectral methods. The compounds are screened for their in vitro antibacterial activity using gram positive bacteria and gram-negative bacteria. Several derivatives of pyrazolines and isoxazolines are produced well to moderate activities against number of bacteria. |
URI: | http://localhost:8080/xmlui/handle/123456789/3235 |
ISSN: | 2078-8665. |
Appears in Collections: | قسم الكيمياء |
Files in This Item:
File | Description | Size | Format | |
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Synthesis and Characterization of Some New Pyrazoline and Isoxazoline Derivatives as Antibacterial Agents.pdf | 454.67 kB | Adobe PDF | View/Open |
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