Immunological Study of Some Pathogenic Bacteria Isolated from Patients with Chronic Kidney Failure

Abstract

Renal failure is one of kidney diseases in which the kidney work in less than 15% of normal, the chronic kidney failure may develop slowly and its irreversible. Many bacterial infection can associate with kidney failure due to low immunity and insufficient kidney infiltration. This study was aimed to investigate the immunological parameters in kidney failure patients. Sixty patients with chronic renal failure reviewed to one hemodialysis center was evaluated, 50 samples with bacterial infection and 10 samples without bacteria in diuresis. The results show significant decease in IgA, IgM, IgG concentrations for patients with bacterial infection 15.24 pg/ml 60.52, 29.9, in compared with uninfected patients which show 59.1, 33.8, 18.3 pg/ ml, the IgE was increased due to the presence of bacteria by 206.6pg/ml. comparing with 186.04 pg/mL in uninfected patients,also IL-1β increased significantly 72.74 pg/ml compared with controls 5.38 pg/ml and a significant decrease in complement C3 in the presence of bacteria at a concentration of 112.45 pg/ml compared with concentration of 155.4 pg/ml in healthy people. This study conclude that the immunological parameters different significantly in patients with chronic kidney failure infected with different bacterial infection in compared with uninfected patients.