Comparing the values of anti-TPO and IL-17 among patients with thyroid disorders and comparing them with healthy controls in Ramadi City

Abstract

Even though most thyroid subjects are undiagnosed due to nonspecific symptoms, universal screening for thyroid disease is not recommended for the general population. In this study, our motive is to compare thyroid autoantibody anti-TPO and IL-17 in addition to traditional thyroid markers TSH, T4, and T3 between two patients' groups (patients with hypothyroidism (TSH) > 6 mIU/L and patients with hyperthyroidism TSH between 0.3 and 6 mIU/L) with a control group. Here a total of 45 subjects were divided into three groups, the first group consisted of 15 patients with hyperthyroidism. The second group consisted of 15 individuals with hypothyroidism, and the control group consisted of 15 healthy individuals. According to our results, an increase in TPO values was observed in all study groups, and the highest increase was recorded in the hyperthyroidism (386.672±116.924), and with regard to interleukin-17 values, a high value was observed in patients with hyperthyroidism (38.1033±5.44) compared to other groups. Our results showcase that anti-TPO appear prior to the onset of thyroid hormone dysfunction in control group And this is an indication of future disorders in the thyroid gland, in addition to the high levels of interleukin in the pathological groups and the high levels of interleukin in the height group, indicating the role of immune disorders in thyroid disorders.