Assessment of oxidative stress and lipid profile in a sample of patients with non-Hodgkin's lymphoma

Abstract

The aim of the current study was to observe the profile of MDA and plasma lipids (Triglyceride, Cholesterol, HDL-Cholesterol, LDL-Cholesterol and VLDL Cholesterol) in patients with non- Hodgkin lymphoma (NHL). Materials and Methods: The research included 100 subject who were divided into two groups; the first as controls (50 in number) and the second as non-Hodgkin lymphoma patients (also 50 in number).Fasting blood samples were taken from each subject controls and patients (During beginning chemotherapy after 21 days from consumption the Dose) at the Unit of endocrine and tumors at Al Ramadi hospital, Iraq, all samples were non-smokers. Further 5 ml Peripheral venous blood samples were taken into tubes after an overnight fasting for at least 10 hours) for assay Sera were kept at -20 °C until utilized. The comparisons taken in this study was disease factor, gender, age and BMI. Results: A significant increase in serum levels (MDA and TG) of patients with NHL was found in all the comparisons made in this study (disease factor, gender, age, BMI). With respect to T.C, the levels had an insignificant fluctuation. It was often found that there was an insignificant decrease in patient levels (disease factor, gender, younger age group), With regard to HDL C, in most of the comparisons (disease, gender, BMI), its decrease was significant and it was not signify ant in comparisons (age). For all comparisons, however, LDL-C saw a non-significant rise. As far as the level of VLDL-C was concerned, its increase was significant for (disease, gender, BMI) and was not significant for comparison (age). Conclusion: The serum lipid profile can be useful in the diagnosis of the disease because the plasma lipid profile of patients with non-Hodgkin lymphoma is modified, Lipid peroxidation of patients with cancer can be critical in determining the activity and nature of the disease. The increase in lipid peroxidation and the propensity of antioxidants to increase in cancer are most likely due to an adaptive answer.