TAUTOMERIC TRANSITIONS WITH PHOTO-INDUCED EFFECTS USING LASER BEAM OBSERVED IN ANTIBIOTIC ERYTHROMYCIN - ESTOLATE

Abstract

The photo transitions of Erythromycin 2-propionate dodecyl sulphate (C40H71NO14, C12H26O4S) using Nitrogen Laser beam have been studied at different periods of time. Different techniques have been used to analyze and identify final products. The results showed that photo transitions of Erythromycin - Estolate which measured by conductivity initially increased and then decreased with time especially at high pulse rate. While pH showed a different behavior and initially there was reduction in pH values by increasing the pulse rate. The kinetic study indicated that the rate of reaction is of the second order type . The qualitative identification showed that the final products were; · First: 6-(4-Dimethylamino-3-O-propionyl –6-methyl- tetrahydro-pyran-2-yloxy)-14- ethyl-4-(5-hydroxy-4-methoxy-4,6-dimethy-tetrahydro-pyran-2-yloxy)-3,5,7,9,11,13- hexamethyl-oxacyclotetradeca-2,10-dione-7,12,13-propaniol dodecyl sulphate. · Second: 6-(4-Dimethylamino-3-O-propionyl –6-methyl- tetrahydro-pyran-2-yloxy)-14- ethyl-4-(5-hydroxy-4-methoxy-4,6-dimethy-tetrahydro-pyran-2-yloxy)-3,5,7,9,11,13- hexamethyl-oxacyclotetradeca-2,9-diene-2,7,10,12,13-pentaol dodecyl sulphate. The final products showed an existaence of enol group through a tautomerism reaction of keto enol.