STUDY THE EFFECT OF SOME ACETYLIC AMINE COMPLEXES ON ACETYLCHOLINE esterase Inhibited by ORGAN PHOSPHOROUS COMPOUND IN BLOOD SERUM

Abstract

In this research , the biological activity for some of new prepared Acetlynic Amine complexes have been study through effect of these complexes to used as activation and reactivation AChE enzyme inhibited by organophosphorous compound which used in herbicide or chemical war in blood serum.The inhibition of AChE by some organophosphorous compounds: TEP=TriethoxyPhosphinoxide, TDMAP=Tris(DiMethylAmine)Phosphenoxide has been studied for the first time. From the degree of inhibition obtained, the time of incubation and inhibitor concentration for the highest inhibition have been determined. The results obtained from (Linweaver –Burk) plot indicates that the inhibition is Non-Competitive.The inhibition percentages obtained confirmed that TEP has a higher inhibition than TDMAP. The fect of (zinc, cadmium and mercury) (II) of acetlynic amine (N-Propargyl pipredine) complexes on the activity of the inhibited enzyme has been studied.The resuls obtained from the incubation time and concentration experiments of the above complexes with inhibited enzyme, showed that all the complexes behave as re-activators.