Isolation, Identification and antibiotic resistance profile distribution of clinical E. coli in Iraqi patients

Abstract

Introduction: Escherichia coli is a Gram-negative, rod-shaped bacterium that belongs to the Enterobacteriaceae family and the Gammaproteobacteria class. E. coli is one of the most prevalent organisms that cause bacterial illnesses. Globally, the rise of multidrug-resistant E. coli poses a significant risk to public health. Antimicrobial resistance in E. coli is causing havoc in the world's healthcare system Aim this study: The goal of this study was to find out how resistant clinical isolates of E. coli were to antibiotics. Methods: Between November 2021 and January2022, a total of 67 clinical samples were obtained from patients, including urine, wound, ear, feces, and sputum samples. The Vitek-2 compact system was then used to confirm E. coli and test susceptibility to various antibiotics. Result: E. coli was discovered to be extremely susceptible to ertapenem, imipenem and amikacin (97.0%), but resistant to ampicillin (94%), and through this study, different resistance patterns to E. coli appeared to us, ranging from MDR, XDR, and PDR. Conclusion: E. coli isolated from different clinical specimens exhibited varying antibiotic sensitivity patterns, with high resistance to conventional antibiotics. Ertapenem, imipenem, and amikacin were found to be the most effective antibiotics against E. coli isolates. Clinical isolates of E. coli, on the other hand, had high resistance to ampicillin, Trimethoprim/ sulfamethoxazole and Ceftazidime Therefore, it is advised that physicians conduct antibiotic sensitivity testing to choose the most effective medications.