Effect of Sonchus oleracea Extract on Some Virulence Factor of Klebsiella pneumonia Which Isolated from Urinary Tract Infection in Ramadi Hospital

Abstract

The plant contains vitamin C, thiamin, riboflavin, and some citrus and saponins. Medical benefits of wrapping Its medicinal benefits are attributed to the similarity between it and chicory Tonic and regulator of sugar level in The blood is a diuretic, a strong purgative, lowers the level of cholesterol in the blood and combats scurvy, as it is anthelmintic Methodology: Klebsiella bacteria were isolated from patients suffering from urinary tract infections in Ramadi General Hospital in selective media (Maconkey Agar), four concentrations of the aqueous and alcoholic extract were made 10%, 20%, 30 % and 40% to test the effectiveness of the extracts in inhibiting growth and virulence factors for bacteria. Result: the effect of the aqueous and alcoholic extracts of the Sonchus oleracea extract on the production of the biofilm of Klebsiella bacteria, where it was observed that there were significant differences in the concentrations of the aqueous and alcoholic extract in reducing the production of the biofilm of the bacteria, and the best concentration of the aqueous and alcoholic extract was 40%, where the biofilm concentration was 31 compared to the rest of the concentrations 3%, 20% and 10%, where its concentration reached .55, .64, and .74, respectively, and compared to the control, where its concentration was .98%. It was not noted that there were significant differences between the concentrations of plant extracts and aqueous and alcoholic extract in Reducing biofilm yield. conclusion the results explain that this plant has many It is one of the effective compounds such as vitamin C, thiamin, riboflavin, and some citrus and saponins. That destroy the cell wall and thus reduce the production of the biofilm and that these compounds increase by increasing the concentration of plant extracts, and this explains the effect of the high concentration in reducing the production of the biofilm.