Study The Relationship Between Smoking And Some Physiological Variables , Genetic Polymorphisms Of Dopamine Beta Hydroxylase In Ramadi Residents Sample .

Abstract

Smoking and the diseases caused by it are one of the largest causes of death in the world at the present time, and it is one of the largest causes of premature death in industrialized countries,The current study was conducted for the purpose of studying the effect of cigarette smoking on a sample of 75 smokers of three age groups, in addition to a control sample consisting of 25 individuals who do not smoke or sit with smokers and of the same age groups, and for the purpose of showing the relationship of dopamine beta-hydroxylase enzyme in smokers and its effect on the genetic future Partially and a case study of the association and effect of some serological factors with smoking for the period from 10/10/2020 to 11/12/2020. The results of the current study showed a significant increase of p≤0.05 in the concentration of LDH enzyme in the serum of the study sample compared with its concentration in the serum of the control sample, In addition to the absence of a significant correlation p≤0.05 between the concentration of dopamine enzyme and the concentration of LDH enzyme in the serum of the study sample members. The results of the current study proved that there was a significant difference, p≤0.05, in the concentration of vitamin D3 in the blood of the study sample, compared to its concentration in the blood serum of the control sample, It was also found from the results of the current study that there was a significant inverse correlation p≤0.05 between the concentration of dopamine enzyme and vitamin D3 in the blood serum of the study sample, The resultsof the current study showed a significant increase, p≤0.05, in the concentration of Ferritin in the blood of the study sample, as compared to its value in the blood of the control sample members While the results of the current study did not show a correlation between the concentration of the dopamine enzyme and the Ferritin in the blood of the study samples. The results of the current study also showed the occurrence of a multiplicity of forms or sites of nitrogenous bases (SNPs), as the site rs6351 , rs429699 and rs6880875 showed a polymorphism In the main sites.