CYTOTOXICITY OF IRON DOPED SULFATED ZIRCONIA NANOPARTICLES: SYNTHESIS, CHARACTERIZATION AND IN VITRO STUDY

Abstract

Nanostructured iron-doped sulfated zirconia was prepared via the precipitation and dry spray technique followed by calcination at 700oC for 5h. The physicochemical characterization of these nanomaterials was performed using X-ray diffraction, X-ray photoelectron spectroscopy and transmission electron microscopy. The average diameter of iron-doped sulfated zirconia nanoparticles is estimated to be 29/nm. The anti-cancer effects of iron-doped sulfated zirconia nanoparticles were examined on the human breast cancer MDA-MB-231, colon cancer HT29 and liver cancer HepG2 cell lines using the MTT (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The study showed that iron-doped sulfated zirconia nanoparticles have potential to be developed into an anti-cancer compound.