Study the Association of Asprosin and Dickkopf-3 with KIM-1, NTpro-BNP, GDF-15 and CPP among Male Iraqi with Chronic Kidney Disease

Abstract

In chronic kidney disease (CKD), kidneys develop injured over time and don’t work properly as in the kidneys for healthy people. At what time the kidneys cannot blood clean, further liquids stay and wastes in the body and which leads to many problems in health, such as high blood pressure (BP) and cardiovascular disease (CVD). In current study, we attempt to examine the association of asprosin (APN) and dickkopf-3 (DKK-3) with kidney injury molecule-1 (KIM-1), N-terminal pro-brain natriuretic peptide (NTpro-BNP), growth differentiation factor 15 (GDF15) and copeptin (CPP) among male Iraqi with CKD. Methods: serum APN, DKK-3, KIM-1, NTpro-BNP, GDF-15 and CPP were determined by ELISA technique in 40 healthy controls (HCs) and 44 male patients with CKD, from the Al-Fallujah teaching hospital were recorded in this paper, serum concentrations of urea, creatinine and estimated glomerular filtration rate (eGFR) were measured by colorimetric methods Results: serum APN and DKK-3 were importantly greater in CKD males than in HCs (P<0.0001) and they positively associated with KIM1, NTpro-BNP, GDF-15 and CPP (P<0.01), also serum concentration of ANP was positively associated DKK-3 (P<01). Studied variables presented the following descending order of area under the receiver operating characteristic (AUROC) curve urea, creatinine and e GFR (1for all, P<0.0001), KIM-1(0.9896), APN (0.939), CPP (0.8966), DKK-3 (0.893), NTpro-BNP (0.8558) and GDF-15 (0.8375) respectively (P<0.0001for all). Conclusion: serum levels APN, DKK3 KIM-1, NTpro-BNP, GDF-15 and CPP may be a biomarker of renal damage in CKD development in Iraqi males.