The Immunological Changes Resulted From Injection Of White New Zealand Rabbits With Cholesterol and Vitamin E.

Abstract

White New Zealand rabbits were injected with three doses (0.3 ml for each dose) of cholesterol and vitamin E with ten days time intervals to study their effects on certain immunological factors that may happen when the are injected. These rabbits were divided into three main groups, the first group (3 animals) was injected with normal 8 saline only, the second group (3 animals) was injected with vitamin E and the third group was injected with cholesterol. Results showed the followings: - The injection with vitamin E showed a higher delayed hypersensitivity with a skin induration of 5.49±0.03 mm and with higher erythema 42.04±6.64mm 2 than cholesterol which showed an induration of 4.43±0.32mm and erythema of 30.66±2.10 mm 2 as compared with the control group which gave 2.17±0.04mm for skin thickness only. - Vitamin E antigen gave a higher percent of phagocytotic activity due to neutrophils 16.25±2.50 % than cholesterol 13.25±2.753 % after 30 days of injection as compared to control 6.66±1.527 %. - Cholesterol gave a higher antibody titer 853.33±295.603 than vitamin E 149.33±97.761 and in control the highest was 2.31±6.66 in animals sera.