Garlic extract and honey as potential protective agents against cadmium-induced Nephrotoxicity in male rats

Abstract

Background: Cadmium (Cd) contamination is a very serious international problem as it can enter into the food chain, become bio-accumulated, and endanger human health. Aim: To determine the protective aqueous potentials of the extract of garlic and honey on toxicity induced by cadmium (Cd) at rats. Materials and Methods: Rats (35 males) were haphazardly categorized into seven groups. Standard group (1) received D.W.; group (2) received aqueous (GAR) extract (two g/kg BW); group (3) received honey (HON) (1,5 g/kg BW); group (4) received CdCl2 (5 mg/ kg BW); Group (5) received aqueous (GAR) extract plus(HON); Group (6) received aqueous (GAR) extract plus (HON), after 6 hour received CdCl2; group (7) received CdCl2 for 4 weeks and then treated with aqueous (GAR) extract plus(HON) for additional 4 weeks. Doses being tested were given orally to rats by gavages approximately for 8 weeks (3 times a week). Results: showed a significant increase in serum urea, creatinine, uric acid, and MDA while a significant decrease in SOD, GSH, and CAT in CdCl2- intoxicated animals (group 4) compared to the control group. Treatment of CdCl2-intoxicated animals with aqueous garlic extract and honey revealed a decline in the harmful Cd influences via restoring antioxidant activities, biochemical modifications, and oxidative stress markers.