ASSOCIATION OF VITAMIN D3 RECEPTOR GENE (BSMI) AND SOME BIOCHEMICAL PARAMETERS IN IRAQI GESTATIONAL DIABETIC PATIENTS

Abstract

Our study was conducted to estimate the association between vitamin D3 receptor gene (BsmI) polymorphism and gestational diabetes mellitus (GDM) patients among Iraqi women. This study involved 40 women with GDM, 30 normal pregnant women as a positive control and 30 non-pregnant women as a negative control. Age (years), body mass index (BMI), Fasting Blood Glucose (FBG), total cholesterol, triglycerides (TG) and lipid profile of the studying groups were determined. DNA sampling was purified and amplified by using PCR. The BsmI genotype was estimated using Restriction Fragment Length Polymorphism (RFLP). The results exposed that the age, BMI, FBG, HbAIc, insulin hormone, insulin resistance, and lipid profile except HDL-C were significantly increased with GDM risk compared to women with normal pregnancies, but there was no significant alterations in concentrations of IGF1 hormone, vitamin D and BsmI (B and b) alleles frequency between GDM and control groups. This study offers that there was no significant correlation between BsmI polymorphism and GDM patients among Iraqi pregnant women