Synthesis of 1-Benzyl-3,6-diazahomoadamantane

Abstract

Condensation of 4-phenylbutan-2-one with tetramethylenediethylenetetramine afforded 1-benzyl-3,6- diazahomoadamantan-9-one, whose nitration provided 1-(4-nitrobenzyl)-3,6-diазаhomoadamantan-9-one. The modifi cation of the nitro and carbonyl groups resulted in the formation of 1-benzyl-3,6-diazahomoadamantane and its derivatives with functional groups at the benzene ring and the bridging carbon atom С9.