Evaluating of 8-Hydroxy-Deoxyguanosine Interleukin-6, Interleukin-7 In Acute Kidney Injury Iraqi Males

Abstract

Background: Acute kidney injury (previously known as acute renal failure) is a sudden loss in kidney function. There are a number of triggers, including blood and fluid loss from accident, dehydration, burns, or surgery, side effects from drugs, cardiovascular disease, infection, liver failure or severe allergic reaction. Objective: The aim of the present study was to assess five important factors in patients with AKI (the amount of 8-OHDG, IL-6, IL-7, Blood Pressure, and Pulses). These factors were surveyed in AKI patients to compare with healthy controls and find out the correlation between AKI and serum 8- OHDG, IL-6, IL-7, Blood Pressure, and Pulses levels Materials & Methods: The study was conducted prospectively between the dates June 2012 and April 2013. Population of the study consists of 41 patients diagnosed with acute kidney injury (AKI) and a control group of 41 healthy people. 8-OHDG, interleukin-6, interleukin-7 and blood pressure levels were evaluated in all subjects. Results: Serum levels of inflammation markers, IL-6 and IL-7 were significantly increased in AKI group versus control group. The percent of DNA damage of peripheral blood mononuclear cells was higher in AKI patients (23.24±10.84 ng/ml) compared to healthy controls (8.30±3.86 ng/ml) (p<0.001). Pearson correlation analysis showed a significant positive correlation of DNA damage with IL-6 and IL-7, but not with Sys.BP, Dia.BP, pulses and age. Conclusion: the results of the present study suggest that 8-OHdG level in Acute kidney injury may be a useful marker of DNA damage also blood 8-OHdG had significantly positive correlation with IL-6 and IL-7. Oxidative stress may serve as a risk factor for the presence of Acute kidney injury in Iraqi men