Correlation of Calprotectin with Galectin-3, Adropin and CTLA-4 in Iraqi Rheumatoid Arthritis Patients

Abstract

Background Rheumatoid arthritis (RA) is a common autoimmune infection described by enduring inflammation and intersections destruction Aim of the work The current research was planned to measure the serum level of calprotectin (Calpro) in cases with RA & its correlation with the galectin-3 (GAL3), adropin (AD) and cytotoxic T lymphocyte as-sociated antigen-4 (CTLA-4). Methods The study concerned on 44 Iraqi patients of RA in compared with 40 healthy control (HC) matched for sex, age and ethnic background, erythrocyte sedimentation rate (ESR) was measured, while serum Calpro, GAL3, AD and CTLA-4 levels were estimated by means of sandwich ELISA test using commercially available kits. Results Serum Calpro, GAL3, CTLA4, was importantly greater (P<0.001) while vitamin D (VD) and AD was significantly lower (P<0.001) in RA patients when compared to control. There was a significant positive association among Calpro and both of (GAL3 and CTLA4). A important negative relationship among Calpro and AD were observed Conclusion The present results explained that serum Calpro is a measurable, useful specific indicator of infection commotion and joint impairment in RA patients