Study the correlation between P-selectin and endotoxin with lipopolysaccharide-binding protein, visfatin, migration inhibitory factor, and soluble thrombomodulin in female Iraqi atherosclerosis patients?

Abstract

Background: Atherosclerosis (AS), it is a prolonged inflammatory illness, including together the native and adaptive immune systems; it controls the beginning and development of the injuries, and possibly devastating thrombotic problems. We designed this study to examine the relationship of P-selectin (SELP) and endotoxin (ET) with lipopolysaccharide-binding protein (LBP), visfatin (VF), macrophage migration inhibitory factor (MIF), and soluble thrombomodulin (STM) in Iraqi AS patients, and to determine the power of this association. Materials and Methods: Serum levels of SELP, ET, LBP, VF, MIF, and STM were measured by ELISA technique in 42AS patients, the age range within 50–74 years and 42 healthy controls, the age within 48–71 years, matched sex, and ethnic background were selected accurately for comparison. Results: Serum SELP, ET, LBP, VF, MIF, and STM concentrations were raised in the AS cases than those without AS (P < 0.01), Pearson’s correlation analysis exhibited that sera SELP and ET concentrations indicated an important positive association with all studied parameters. Receiver operating characteristic curve analysis showed that a SLEP has the best discrimination among the individual AS markers with area under the curve 0.9421 (95% confidence interval 0.8975–0.9868; standard error 0.02280; P < 0.0001). Conclusion: Serum studied parameter levels could provide additional information about the risk factors of developing AS disease and may be used as predicators for AS growth also may be used in manufactured of new therapy agents to reduce or prevent AS disease