Exploration of the Relationship between Interleukins 17, 37 and 38 with Vitamin E in Iraqi Men with CHB

Abstract

Hepatitis B is a possibly life-threatening liver contagion produced by the hepatitis B virus (HBV). It is a main worldwide health issue. It can cause chronic contagion & puts societies at great danger of death from cirrhosis & liver malignancy. The goal of the current research was to measure four important parameters in cases with chronic hepatitis B (CHB) (the amount of IL-17, IL-37, IL-38 & vitamin E). These factors were surveyed in CHB patients to compare with healthy controls & study the association among these markers with other parameters in the study. Population consists of 40 patients diagnosed with CHB & a healthy controls (HC) group of 39 person. IL-17, IL-37, IL-38 & vitamin E levels were assessed in all subjects by using available ELISA kits from Mybiosource company; USA. serum concentrations of IL-17 & IL-37 were importantly greater in HBV group compared to control group, while serum levels of IL-38 & vitamin E were importantly lesser in CHB cases compared to HC also vitamin E showed weakly negative correlation with IL-17 & weakly positive correlation with IL-37 & IL-38. The study recommends that IL-17 & IL-37 levels may be a useful indicator to identification HBV in primary phases so that we should monitor these markers concentrations in blood of constantly to sustain their health.