A Relationship of Periostin with some Bio- parameters in Type2 Diabetic Patients without and with COVID19

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a prolonged disease characterized by hyperglycemia resultant from weakening in insulin secretion, insulin action or both. T2DM and its associated metabolic disorders have been stated as the main cause in coronavirus disease 2019 (COVID-19). Current study was designed to investigate the association of periostin with some parameters in T2DM patients without and with COVID19. Materials and methods: This study involved of 56 patients, 28 with T2DM without any complications, the other 28 have T2DM with COVID19 attending Al-Fallujah teaching hospital, and 28 healthy persons matching in age, gender and ethnic background as control group. Serum level of periostin was estimated by ELISA technique while urea and creatinine were assessed by colorimetric enzymatic methods. Total protein and albumin were determined by biuret method. Results: Serum level of periostin was elevated in the T2DM patients without and with COVID19 than in healthy controls (HCs). The levels of urea and creatinine were importantly higher in T2DM patients without and with COVID 19 than in HCs (P < 0.000l), while total protein and albumin were lower in T2DM patients without and with COVID 19 than in HCs (P < 0.000l). Periostin had significant positive association with fasting serum glucose (FSG), HbA1c, urea creatinine, BMI, and ALB/GLB (P<0. 01), while negative association between total protein and albumin (P<0. 01) was observed. Studied biomarkers offered the following descending order of area under the receiver operating characteristic (AUROC) curve FSG and HbA1c (1), periostin (0.9764( , urea (0.6569), albumin and ALB/GLB (0.641), total protein (0.6147), creatinine (0.611) and globulins (0.611). Conclusion: Serum level of periostin may be used as a novel biomarker in diagnosis T2DM without and with COVID19