ROLE OF APPLE SEED EXTRACT ON RAT LIVER TOXICITY CAUSED BY TRAMADOL

Abstract

ABSTRACT : The study hypothesized that apple seed extract(APS) will have associate anti-oxidative action and therefore mitigate cellular harm and scale back the progression of infectious disease and progress towards liver harm. Therefore, the current study is intended to analyze the potential helpful result of apple seed extract against liver harm caused by excessive use of tramadol (TRA). Male rats were administered oral tramadol (3mg/kg/bw) for two weeks and so orally extracted apple seeds at a degree of (15 mg/kg/bw) for two weeks. Tramadol-treated rats with apple seed extract showed maintaining weight whereas up Don quantitative relation and blood serum markers of liver operate together with angular position, ALP, AST, GGT, simple protein and total hematoidin, Apple seed extract reduced the rise in MDA and H2O2 levels and normalizes the amount of SOD, GSH and CAT within the liver. Lastly, apple seed extract has sturdy therapeutic potential in reducing liver harm caused by taking tramadol.