The Study of Selenium’s Effect on Immunological Response in Guinea Pigs

Abstract

Abstract The purpose of this study is to determine the effect of the selenium on immunity, used some immunological tests in humoral and cellular immunity.. eighteen guinea pigs were divided in to three Groups(6 animals for each Group).the 1st group (S1) supplied with a selenium (0.02 milligram) ,the 2nd group(S2) supplied with (0.04 milligram). 3rd group served as a control group received distills water instead. (Animals were treated daily with these minerals using stomach tube for two months).The serological test used to evaluate antibody level was ELISA test. Animals were immunized with S typhi antigens, Animals respond to S typhi antigen. Significant differences were detected in the treated group in comparison with the control. on the other hand no significant differences were seen between treated groups . Selenium showed significant effect on cell-mediated immunity in vivo as detected for delayed type hypersensitivity (DTH) reaction, this effect was supported by an in vitro test using migration inhibition assay (MIF).