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DC Field | Value | Language |
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dc.contributor.author | Ali S.Abed, Ahmed Mishaal Mohammed | - |
dc.contributor.author | Yousif H. Khalaf | - |
dc.date.accessioned | 2022-10-29T14:07:08Z | - |
dc.date.available | 2022-10-29T14:07:08Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/7641 | - |
dc.description.abstract | Nanotechnology has demonstrated the ability to produce anti-cancer nanoparticles in an environmentally friendly method. This study demonstrates the use of photothermal therapy (PTT) in treating the MCF-7 cell line in a concentration and time-dependent manner. In this study, the MTT assay was employed to evaluate the cytotoxicity of platinum nanoparticles (Pt-NPs) synthesized through green chemistry using two aqueous extracts of Ziziphus spina christi and Cordia myxa L. leaves in synergy with near-infrared radiation (NIR) against MCF-7 cells. Our results demonstrated a higher inhibition of Pt-NPs prepared from Cordia myxa L. leaf extract against MCF-7 cells compared to Ziziphus spina christiin leaf extract. Furthermore, the acridine orange- propidium iodide assay showed the ability of Pt-NPs to convert NIR at 808 nm to sufficient local heat to induce an apoptosis pathway in the MCF-7 cells. Where, the temperature was recorded at 47 ◦C with a cytotoxicity of about 78 % at the highest concentration (40 µg/mL) and at an irradiation time of 120 sec. Taken together, the radiation was found to enhance the properties of Pt-NPs as an anti-cancer agent against MCF-7 cells by converting absorbed light into heat in a short time. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier BV | en_US |
dc.subject | Platinum | en_US |
dc.subject | Photothermal | en_US |
dc.subject | Nanoparticles | en_US |
dc.subject | Cancer | en_US |
dc.title | Novel photothermal therapy using platinum nanoparticles in synergy with near-infrared radiation (NIR) against human breast cancer MCF-7 cell line | en_US |
dc.type | Article | en_US |
Appears in Collections: | كلية الصيدلة |
Files in This Item:
File | Description | Size | Format | |
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Novel photothermal therapy using platinum nanoparticles in synergy with.pdf | 12.15 MB | Adobe PDF | View/Open |
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