Relationship between bmi and risk factor of breast cancer

Abstract

Abstract Breast cancer is the commonest cancer affecting women worldwide. Different studies have dealt with the etiological factors of that cancer aiming to find a way for early diagnosis. This investigation was carried out on 74 patients (all were females) who received satisfactory therapy. The present study investigated the relationship between BMI and evaluation of some etiological risk factors among breast cancer patients in Iraq. They were confirmed for breast cancer by histopathological examinations at Nanakali Hospital in Erbil. All women were between 20-72 years. Ages ,Weight ,height, stage(II,III), hormone receptors ER,PR and Her2 were taken into account as risk factors. Among the breast cancer patients, 45% were pre-menopausal and 28% were menopausal and 27% were post-menopausal. Body mass index (BMI) is widely used as a measure of obesity .we investigated the relationship between obesity ( BMI >= 30 kg/m2 ) and outcomes in women with ER-positive early stage breast cancer. Women with high BMI presented with more aggressive stage at the time of diagnosis. Their tumor usually show positive hormonal status (ER/PR), HR+/Her2- being the most Predominant molecular subtypes. most of obese women have tumor hormonal status positive with favorable molecular subtype (ER+/Her2- ), thus Decreasing weight will mainly contribute to decrease tumor exposure to high endogenous estrogen especially in postmenopausal age, dramatically effect response to treatment in return.