"SYNTHESIS, CHARACTERIZATION AND KINETIC STUDIES OF SOME OXAZEPINE AND OXAZEPANE FROM REACTION OF ETHYLIMINO AND DIETHYLIMINO WITH MALEIC, SUCCINIC AND PHTHALIC ANHYDRIDE"

Abstract

ABSTRACT: Ethylimino and Di Ethylimino were prepared by condensation of Ethylene diamine with one equivalent and tow equivalent of substituted benzaldehyde. These ethylimino were reacted with one equivalent of maleic , succinic and phthalic anhydride in absolute ethanol to give 7-membered heterocyclic ring system of 3-(2-amino-ethyl)-2-(2-hydroxy-phenyl)-[1,3] oxazepine and 3-(2-amino-ethyl)-2-(2-hydroxy-phenyl)-[1,3] oxazepane. Diethylimino were reacted with tow equivalent of maleic and succinic anhydride in same condition to give 2(7-membered) heterocyclic ring system of 2-(2- hydroxy-phenyl)-3-{2-[2-(2-hydroxy-phenyl) -4,7-dioxo -[1,3] oxazepine-3-yl]- ethyl}-2,3-dihydro-[1,3]oxazepine-4,7-dione and 2-(2-hydroxy-phenyl)-3-{2-[2-(2- hydroxy-phenyl) -4,7 -dioxo -[1,3] oxazepane-3-yl]-ethyl}-2,3-dihydro- [1,3]oxazepane-4,7-dione. Kinetic Studies of reaction of Ethylimino and DiEthylimino with maleic , Succinic and phthalic anhydride proved to A firstclass equation was applied to the reaction.