Preparation of some hydroxamic acid derivatives from Honey wax compounds and study the biological activity on cancerous tumors

Abstract

"Abstract: In this paper, a number of hydroxamic acid derivatives were prepared from one of the esteric compounds found in beeswax. Where the compound (Palmito Hydroxamic acid) was prepared, by reacting beeswax with hydroxyl amine hydrochloride and using sodium hydroxide as the base medium (pH= 13) with a heat escalation at a temperature of (80°C), and for two hours. From this compound , the two compounds (N-acetoxy- Palmetto Hydroxamic acid)and (N-acetyl-N- acetoxy- Palmito Hydroxamic acid) were prepared by reacting compound (Palmito Hydroxamic acid ) with acetyl chloride and in certain molar ratios.The synthesized compounds were purified and their melting point was determined. Also, these compounds were diagnosed using( UV.VIS) infrared spectroscopy (,(FT.IR ),) and the use of ( H-NMR). he biological efficacy of these derivatives prepared as anti-cancer tumors was studied by using one type of cancer cellular lines for human carcinogenic muscle tissue. By analyzing the results obtained statistically, these compounds were found to have a significant effect on the growth of these cells. Some of these compounds have inhibition effects on the growth of metamorphic cells. The biological antibacterial activity of these synthesized compounds was studied, using two gram - negative and gram - positive pathogenic bacteria. The synthesized compounds exhibited different inhibition capacities, different diameters, depending on the type and concentration of the compound used, as well as the type of bacteria used for the study."