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http://localhost:8080/xmlui/handle/123456789/8114| Title: | Formulation of a sustained release docetaxel loaded cockle shell-derived calcium carbonate nanoparticles against breast cancer. |
| Authors: | Nahidah Ibrahim Hammadi, Yusuf Abba, Mohd Noor Mohd Hezmee, IntanShameha Abdul Razak |
| Keywords: | Breast Cancer cancer therapy cockle shell- derived calcium carbonate nanoparticles; Dyge delivery |
| Issue Date: | Apr-2017 |
| Publisher: | Pharmaceutical Research An Official Journal of the American Association of Pharmaceutical Scientists |
| Citation: | 56 |
| Abstract: | Purpose: Here, we explored the formulation of a calcium carbonate nanoparticle delivery system aimed at enhancing docetaxel (DTX) release in breast cancer. Methods: The designed nano- anticancer formulation was characterized thorough X-ray diffraction (XRD), Fourier transformed infrared (FTIR), transmission electron microscopy (TEM) and field emission scanning electron microscopy (FESEM) and Brunauer-Emmett-Teller (BET) methods. The nano- anticancer formulation (DTX- CaCO3NP) was evaluated for drug delivery properties thorough in vitro release study in human body simulated solution at pH 7.4 and intracellular lysosomal pH 4.8. Results: Characterization revealed the successful synthesis of DTX- CaCO3NP, which had a sustained release at pH 7.4. TEM showed uniformly distributed pleomorphic shaped pure aragonite particles. The highest entrapment efficiency (96%) and loading content (11.5%) were obtained at docetaxel to nanoparticles ratio of 1:4. |
| URI: | http://localhost:8080/xmlui/handle/123456789/8114 |
| ISSN: | 07248741, 1573904X |
| Appears in Collections: | كلية الصيدلة |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| First .pdf | 2.38 MB | Adobe PDF | View/Open |
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