CHARACTERIZATION, HISTOLOGICAL EVALUATION AND EFFICACY OF DOCETAXEL-LOADED COCKLE SHELL-DERIVED CaCO3 NANOPARTICLES IN VITRO AND IN VIVO

Abstract

Breast cancer is one of the most widely researched cancers worldwide. Currently, therapeutic options aimed at reducing its metastasis have a limitation of toxicity to the patient. Cockle shell-derived calcium carbonate aragonite nanoparticles (CSCaCO3NP) have shown promising potentials as a slow drug releasing compound in cancer chemotherapy. This study explores CSCaCO3NP as a delivery system aimed at enhancing docetaxel (DTX) release in breast cancer. Furthermore, this study also evaluated the in vitro cytotoxicity of DTX-loaded CSCaCO3NP against 4T1 cell line, and in vivo toxicity evaluation of CSCaCO3NP, and the effect of DTX-loaded CSCaCO3NP in 4T1 cancer-bearing Balb/C mice.