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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Nahidah Ibrahim Hammadi | - |
| dc.date.accessioned | 2022-11-04T23:23:32Z | - |
| dc.date.available | 2022-11-04T23:23:32Z | - |
| dc.date.issued | 2018-08 | - |
| dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/8123 | - |
| dc.description.abstract | Breast cancer is one of the most widely researched cancers worldwide. Currently, therapeutic options aimed at reducing its metastasis have a limitation of toxicity to the patient. Cockle shell-derived calcium carbonate aragonite nanoparticles (CSCaCO3NP) have shown promising potentials as a slow drug releasing compound in cancer chemotherapy. This study explores CSCaCO3NP as a delivery system aimed at enhancing docetaxel (DTX) release in breast cancer. Furthermore, this study also evaluated the in vitro cytotoxicity of DTX-loaded CSCaCO3NP against 4T1 cell line, and in vivo toxicity evaluation of CSCaCO3NP, and the effect of DTX-loaded CSCaCO3NP in 4T1 cancer-bearing Balb/C mice. | en_US |
| dc.language.iso | en | en_US |
| dc.subject | Breast cancer, | en_US |
| dc.subject | Docetaxel | en_US |
| dc.subject | Cockle shell | en_US |
| dc.subject | Drug delivery | en_US |
| dc.subject | Balb/C Mice | en_US |
| dc.title | CHARACTERIZATION, HISTOLOGICAL EVALUATION AND EFFICACY OF DOCETAXEL-LOADED COCKLE SHELL-DERIVED CaCO3 NANOPARTICLES IN VITRO AND IN VIVO | en_US |
| dc.type | Thesis | en_US |
| Appears in Collections: | كلية الصيدلة | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| PhD Thesis.pdf | 12.65 MB | Adobe PDF | View/Open |
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