A Study of Some Physiological and Molecular Variables for Infertility Women in Anbar Province-Iraq

Abstract

Infertility is a global health problem and one of the major problems in many countries, including Middle East, this phenomenon grow in recent years, as the world has seen a rise in the rates of infertility, especially women infertility, so this study conducted to find some reasons of unexplained women infertility. The current study included (100) infertile women in Anbar province, the ages ranged from 20-45 years of revisions to Al-Ramadi Education Hospital for women and pediatric and some medical clinics in a number of cities and districts of Anbar province, through the period from September / 2013 to January / 2014, in addition to (40) healthy women who did not have any history or clinical signs of infertility and their ages matches of the study group, the results of the current study showed that the proportion of primary infertility in Anbar province, the highest of secondary infertility, amounting to 60% and 40% respectively. The study also included some hormonal tests to members of study and control samples included measurement of Luteal hormone concentration (LH), Follicle Stimulation hormone (FSH), Prolactin hormone (PRL) and Testosterone Hormone (Testo) to excluding any sample suffer from hormonal disorders the study showed a significant increase P≤0.05 in the concentrations of infertile women hormones as compared with the control group, and it was found among the (100) infertile women that 59 (59%)women have different hormonal disorders. A molecular study of 28 infertile woman (do not suffer from any hormonal disorders) in addition to (30) healthy women from the control samples for the detection of polymorphism and disorders that may occur to the aromatase gene CYP19A1 using a pair of specific primers designed throughout this study to determining its relationship with unexplained infertility in women, and showing that there disorders in 25 (89.3%) sample of infertile women ranged from the absence of the primers bands or appearance differs from the expected size while the control group did not show any disturbance.